The mechanism of acute renal failure after uranyl nitrate.
نویسندگان
چکیده
منابع مشابه
The Mechanism of Acute Renal Failure after Uranyl Nitrate ROLAND
Portions of this work were presented at the Annual Meeting of The American Federation for Clinical Research, Atlantic City, N. J., 5 May 1974. Received for publication 21 June 1974 and in revised form 18 November 1974. dose UN (0.047±0.013) and high dose (0.024±0.003 nVs/g kidney wt/mm Hg). Therefore UN decreases GFR by two mechanisms: (a) tubular damage leading to back-diffusion of solutes and...
متن کاملExperimental acute renal failure induced by uranyl nitrate in the dog.
The diminished glomerular filtration rate observed in previous studies of acute renal failure induced by uranyl nitrate has been ascribed to backflow of glomerular filtrate through necrotic tubular epithelium, since renal blood flow was essentially normal. Renal blood flow (xenon washout) and renal function were studied serially for 96 hours after the administration of uranyl nitrate (10 mg/kg,...
متن کاملGlomerular endothelial cells in uranyl nitrate-induced acute renal failure in rats.
In uranyl nitrate (UN)-induced acute renal failure (ARF) glomerular ultrafiltration coefficient (K(f)) decreases because of unknown reasons. Since transport of water across the glomerular capillary wall occurs predominantly extracellularly through the endothelial fenestrae (EF), a reduction in the diameter and/or the density of EF can reduce the extracellular filtration area and the glomerular ...
متن کاملPharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with uranyl nitrate-induced acute renal failure.
Because the physiological changes that occur in patients with acute renal failure could alter the pharmacokinetics of the drugs used to treat the disease, the pharmacokinetics of DA-1131, a new carbapenem antibiotic, were investigated after 1-min intravenous administration of the drug (50 mg/kg of body weight) to control rats and rats with uranyl nitrate-induced acute renal failure (U-ARF rats)...
متن کاملacute renal failure after cardiac surgery
acute renal failure (arf) following cardiac surgery occurs in 1 to 10% of patients. patients who develop arf have higher rates of mortality. this study was undertaken to estimate the role of perioperative variables in predicting of post cardiac surgery arf. we studied a cohort of 398 adult patients who underwent cardiac surgery at our institution from february 2004 to february 2006. adult patie...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1975
ISSN: 0021-9738
DOI: 10.1172/jci107970